Free Scientific Leader, Discovery DMPK Project Specialist

Published date: December 20, 2022
  • Location: Connecticut, United States

ViiV Healthcare is a global specialty HIV company, the only one that is 100% focused on researching and delivering new medicines for people living with, and at risk of, HIV. ViiV Healthcare is highly mission-driven in our unrelenting commitment to being a trusted partner for all people living with and affected by HIV. Our aim is to think, act, and connect differently through a focus on education on for the prevention and treatment for HIV. We go to extraordinary lengths to deliver the sorts of breakthroughs, both in prevention, treatments, care solutions and communities, that really count. We go beyond the boundaries of medicine by taking a holistic approach to HIV through developing and supporting sustainable community programs and improving access to care. We are fully committed to push through every challenge until HIV/AIDS is eradicated. ViiV Healthcare has played a significant part in delivering breakthroughs that have turned HIV into a manageable health condition. We offer the largest portfolio of HIV medicines available anywhere, and we continue our work to cater for the widest possible range of needs in response to the HIV epidemic.

We are aware of how much is at stake for those at-risk or affected by HIV and we show up every day 100% committed to the patients. Our work culture is fast-paced, diverse, inclusive, competitive, and caring. But ViiV Healthcare isn’t just somewhere to work – it’s a place to belong, an invitation to bring your very best, and a team full of impact-driven team members who are hungry to make a difference.

While we have been improving lives of HIV patients for 30 years, this is an especially exciting time to be at ViiV Healthcare, as we evaluate novel approaches to treatment and prevention that could further reduce the impact of HIV on individuals and communities.

Position Overview

ViiV Healthcare is looking for a Scientific Leader to join the Discovery DMPK (drug metabolism and pharmacokinetic) team based in Branford CT as a Project Specialist focused on discovering new medicines for the treatment, prevention and cure of HIV. The DMPK Project Specialist ensures that our DMPK science is embedded in Discovery projects across all modalities (small and large molecule) and is accountable for driving the translational understanding of drug disposition and pharmacokinetic-pharmacodynamic (PKPD) approaches for projects that may include both oral and injectable long-acting medicines. The role requires working within matrix teams to design, complete and interpret in vitro and in vivo ADME studies, providing DMPK strategic leadership to discovery project teams, and contributing to the overall direction of our DMPK science to ensure that innovation is aligned with portfolio deliverables.

This role will provide the opportunity to lead key activities and to progress your career. These responsibilities include:

Drive the DMPK strategy for multiple Drug Discovery stage projects from early lead optimization through to candidate selection
Ensure that translational PKPD approaches and appropriate screening cascades with multi-parametric optimization are being applied to assigned Discovery projects
Efficiently manage their time and project requests for DMPK assays to ensure optimal support of projects across different modalities in the ViiV Discovery pipeline.
Responsible for coordinating and delivering high-quality DMPK written contributions to technical documents
Develop and maintain excellent working relations with key stakeholders in Discovery project teams, in order to ensure strategic alignment
Actively support cross-DMPK initiatives as a representative from the ViiV Nonclinical Safety and DMPK team in order to drive DMPK science and operations.
Why you?
Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

MS Degree (7 years’ experience) or PhD (3 years’ experience) in a field relevant to DMPK (e.g., Pharmacology, Biochemistry, Pharmacokinetics or Drug Metabolism)
Experience working in cross-matrix teams, with demonstrated experience in project milestone delivery
Preferred Qualifications:

If you have the following characteristics, it would be a plus:

PhD in a field relevant to DMPK (e.g., Pharmacology, Biochemistry, Pharmacokinetics or Drug Metabolism) with >5 years drug discovery experience
Demonstrated ability to apply state-of-the-art DMPK science in projects to enable the discovery of new medicines, including experience with small molecules and biologics drug discovery and/or development
Ability to manage DMPK related project resources and budgets
In-depth experience in DMPK representation in Discovery projects across different modalities (e.g., small molecule, mAb, long-acting injectable) and has strong experience in human dose prediction
Examples demonstrating the successful selection of drug candidates through efficient ADME screening cascades such as multi-parametric optimization, translational PKPD and human dose optimization strategies
Experience in leveraging modeling approaches and predictive science in Discovery projects to accelerate timelines and increase probability of success
Excellent communication skills and collaboration as demonstrated through publication and/or external interactions (e.g., university collaborations, speaking invitations, etc.)
Why ViiV?
At VIIV HEALTHCARE, we have already achieved unprecedented change over the past four years, improving R&D, becoming a leader in consumer healthcare, strengthening our leadership and transforming our business execution. Today, we're making the most significant changes we've made to our business in over 20 years.

We are on track to separate and create two new companies in 2022: New ViiV HEALTHCARE with a portfolio of leading vaccines and specialty medicines as well as R&D based on immune system science and genetics; and a new world-leading consumer healthcare company with valued and trusted brands.

A new ambition comes with a new goal. For New VIIV HEALTHCARE, it's about uniting science, talent and technology to get ahead of disease – all with a clear ambition to impact human health, achieve greater and more sustainable returns for shareholders and create a new VIIV HEALTHCARE where exceptional people thrive.

Getting ahead means preventing diseases as well as treating them. We will achieve this through our people and our culture. A culture that is ambitious for patients – so that we deliver what's important better and faster; Responsible for impact – with clear ownership of goals and support for success; and where we do what is right.

So, if you're ready to improve the lives of billions of people, join us at this exciting time in our journey. Join our challenge to move forward together.

NOTE: This position summary is not intended to be all-inclusive. Employee may perform other related duties as negotiated to meet the ongoing needs of the organization.





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